Out of all of those 1, follicles only one has the chance of reaching ovulation. During ovulation, a mature egg is released from the follicle. In addition to the follicles lost during your natural ovulatory cycle, there are additional outside forces like smoking that have the power to accelerate the loss of these follicles we review all of these damaging lifestyle factors in depth in the book, Everything Egg Freezing.
Because things like smoking accelerate the loss of follicles, it has the ability to accelerate aging in general, leading to cases of premature menopause. In short, a combination of nature and nurture can will define how many follicles are left in your ovaries now commonly referred to as your, "ovarian reserve" and how quickly they will disappear before you hit the inevitable mark of natural infertility, menopause.
DID YOU KNOW: You can carry and birth a baby even if you're going through menopause, you just have to use younger, quality eggs and have them fertilized and implanted whether they're your own younger eggs or those received from a donor. Pretty wild, right? AFC is just one of the tests that can help paint a picture of how many follicles you have left in your ovaries - what's referred to as your "ovarian reserve.
It's important to note that even these biological markers are not completely accurate e. Yes, you will probably have a harder time conceiving, and if you do, you might have a higher chance of miscarriage, but it does not mean that you are completely infertile. After proper counseling from your doctor, having information about your existing ovarian reserve can help you understand how many fertile years you may have left, which allows you to make a more informed decision about whether or not fertility treatment like egg freezing is right for you.
AFC is used as a predictor of the number of mature or "dominant" follicles that are capable of being stimulated by the hormone injections taken before the egg retrieval takes place. And because the more eggs you have retrieved is directly correlated with an increased chance of one of them becoming a healthy baby down the line , doctors can use the AFC to anticipate how many eggs you might get in an ovarian stimulation cycle for egg freezing or IVF.
In order to count the number of antral follicles in your ovaries at a given time, you'll need to make an appointment at your fertility clinic where your doctor or a trained technician will perform an ultrasound. This isn't the kind of ultrasound that's often depicted on TV and movies with a wand on your tummy, this one is conducted transvaginally we'd rather explain this upfront in order to prevent any surprises!
In this exam, a wand-like ultrasound device called a transducer is covered with a condom and lubrication and gently inserted into your vagina.
This wand emits the ultrasound waves internally. Lower levels of FSH cause the smaller follicles to grow more slowly or even stop growing, while the bigger follicle continues its steady development. Eventually, one follicle becomes the dominant follicle; the others stop growing and disintegrate. When the follicle reaches close to its maximum size, it releases even more estrogen. Very high levels of estrogen trigger the pituitary gland to produce and release LH, or luteinizing hormone.
This pushes the follicle to complete its last stages of development. Finally, the follicle will burst open and release an egg. This is the moment of ovulation. You might think that follicular development starts and ends during the follicular phase of the menstrual cycle, but that is not the case. The full follicular lifecycle begins before a person is even born, when the ovaries are first developed in a growing fetus.
At this time, the ovaries contain only primordial follicles. It takes anywhere from six months to one year to go from a primordial follicle to a mature, ovulation-ready follicle.
At every stage of follicular development, many follicles stop development and die. Not every primordial follicle will go through each stage. Think of it as a competition to get to the Olympics of ovulation. Some follicles will drop out, and others will continue. The stages of folliculogenesis are:. During these ultrasounds, the number of developing follicles will be counted. They will also be measured. Follicles are measured in millimeters mm. This is around 18 mm.
A mature follicle that is about to ovulate will measure anywhere between 18 and 25 mm. The desirable number of follicles is different for various fertility treatments. You need more follicles for in vitro fertilization IVF , for example. Ideally, you only want one or two good size follicles during a Clomid cycle.
You may feel disappointed when you find out only one or two follicles are big enough to ovulate. Every mature sized follicle could release an egg, and that egg could become fertilized. If you have two follicles, you could conceive twins. Or you might conceive one baby. Or, you might not conceive at all. As with Clomid, ideally, you only want one or two follicles to grow to maturity.
Injectable fertility drugs gonadotropins come with a higher risk of a multiple pregnancy. If you get four or more follicles, your doctor may cancel your treatment cycle. The risk of conceiving triplets or quadruplets is high with so many mature follicles.
During IVF treatment , your doctor wants to stimulate your ovaries to mature several follicles. Anywhere between 8 and 15 follicles is considered an acceptable amount. During an egg retrieval, your doctor will aspirate the follicles with an ultrasound-guided needle. The IVF process can be emotionally, financially, and physically stressful.
In addition to these stress points, there is also a learning curve, as there are many new medical fertility terms related to IVF treatments that most people do not understand initially.
One of these terms, follicle, is a term that you will hear again and again as you begin IVF treatment. A follicle is a sac filled with fluid in which an immature egg develops. Each monthly menstrual cycle a number of follicles, each containing an egg, are selected to grow and mature. However, most of this group of follicles do not reach maturity but fade away.
Each month, one follicle is selected and goes on to maturity. When this follicle has matured and grown to the right size the follicle ruptures and releases the egg, which is now ready to be fertilised. This is usually around 14 days after the beginning of the menstrual cycle. Follicles secrete hormones which trigger different stages of the menstrual cycle.
Usually there is one egg per follicle. The egg in this instance is the female reproductive cell, also called an ovum or oocyte. During each monthly menstrual cycle several follicles, each of which contains an egg, begin the process of maturing. However, usually only one of these follicles reaches maturity, and because of this, only one is then selected to grow to a stage where it is ready to release the egg. This usually happens around 14 days into the monthly menstrual cycle.
Follicles and their size and status are a vital part of assessing fertility and fertility treatment. Then from the first menstruation a follicle is selected. It is thought that the higher quality follicles are selected first.
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